Journal of Musculoskeletal Trauma

Tendon Healing: A Review of Basic Science and Current Progress: Young Woo Kwon, Pei Wei Wang, Jun-Ku Lee; J Korean Fract Soc 2020;33(4):227-237. Published online October 31, 2020; DOI: https://doi.org/10.12671/jkfs.2020.33.4.227

Abstract PDF: The tendon connects the muscles to the bones and transmits the loads generated by the muscles to the bones to move the joints, support the joints, and provide stability to the joints. Approximately 30% of patients complaining of musculoskeletal pain are associated with tendon disease, and approximately 50% of musculoskeletal injuries are caused by a tendon injury. Despite this frequent treatment of tendon damage, studies on the basic biology that provide scientific evidence for treatment, such as development, tendon injury, and healing, are still very limited. This review first summarizes the classification and composition of the tendon identified so far, the surrounding tissue, and the blood supply to the tendon. The limitations of the tendon recovery process after a tendon injury are also discussed. Finally, this review examines ways to improve tendon recovery and the biological approaches and tissue engineering that have been currently studied. In conclusion, innovative progress in promoting tendon healing has not been achieved despite the many advances in the basic structure of the tendon, and the cell and regulatory molecular factors involved in tendon recovery. Biological approaches and tissue engineering, which have become a recent issue, have shown many possibilities for the recovery of damaged cases, but further research will be needed until clinical application.

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Current Concepts of Bone Healing: Dong Hun Suh, Bong Mo Koo, Jong Woo Kang; J Korean Fract Soc 2020;33(3):171-177. Published online July 31, 2020; DOI: https://doi.org/10.12671/jkfs.2020.33.3.171

Abstract PDF: Bone injuries induce an inflammatory response that promotes bone healing. On the other hand, an aberrant process, where inflammation becomes chronic, can inhibit the healing of injured bone. At the first stage of the bone healing process, inflammatory cells, such as neutrophils and macrophages, are assembled and secrete various cytokines, chemokines, and growth factors. During callus formation, cells differentiated from mesenchymal stem cells, such as osteoblasts and chondrocytes, play leading roles in bone healing. Currently, various treatment modalities have been developed through the known mechanism of bone healing, and the clinical outcomes of bone defect and fracture nonunion have been good.

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Current Concepts in the Articular Cartilage Repair: Eui Dong Yeo, Whi Je Cho, Young Koo Lee; J Korean Fract Soc 2020;33(3):164-170. Published online July 31, 2020; DOI: https://doi.org/10.12671/jkfs.2020.33.3.164

Abstract PDF: Articular cartilage defects are common in orthopedic practice. Most clinical and research efforts focus on restoring the damaged cartilage in connection with osteoarthritis or trauma. This article explains the current clinical approaches for repairing cartilage, as well as the research approaches and those under translation into clinical practice. Tissue engineering techniques are being employed with aims of repopulating a cartilage defect with hyaline cartilage containing living chondrocytes with hopes of improving the clinical outcomes. Cartilage tissue engineering involves the cell source, biomaterial and membranes, and growth stimulators. Tissue engineering is being applied to clinical medicine by autologous chondrocyte implantation or similar techniques. While basic science has refined orthopedic treatment of chondral lesions, available evidence does not conclude the superiority of tissue engineering methods over other techniques in improving the clinical symptoms or restoring the native joint mechanics.

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Bone Substitutes and the Advancement for Enhancing Bone Healing: Dong Hyun Lee, Ji Wan Kim; J Korean Fract Soc 2017;30(2):102-109. Published online April 30, 2017; DOI: https://doi.org/10.12671/jkfs.2017.30.2.102

Abstract PDF

With an aging population and the development of surgical techniques, there is a growing demand for bone reconstruction in areas of trauma, arthroplasty, and spinal fusion Although autogenous bone grafting may be the best method for stimulating bone repair and regeneration, there are still problems and complications, including morbidity related to bone harvesting and limitation of harvest amount. Allogeneic bone grafts have a limited supply and risk of transmission of infectious diseases. Over the past several decades, the use of bone substitutes, such as calcium phosphate, has increased; however, they have limited indications. Biomedical research has suggested a possibility of stimulating the self-healing mechanism by locally transmitting the external growth factors or stimulating local production through a gene transfer. In this review, we evaluate recent advances, including bone graft, bone substitutes, and tissue engineering.

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