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HOME > J Musculoskelet Trauma > Volume 33(4); 2020 > Article
Review Article Bone Substitutes: From Basic to Current Update
Jong Seong Han, Hyung Keun Song
Journal of Musculoskeletal Trauma 2020;33(4):238-244.
DOI: https://doi.org/10.12671/jkfs.2020.33.4.238
Published online: October 31, 2020
Department of Orthopedic Surgery, Ajou University School of Medicine, Suwon, Korea

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Abstract

Bone substitutes are being used increasingly in bony surgery as more than two million bone grafts are performed worldwide per year. Autobone grafts represent the gold standard for bone grafting, but morbidity and limited availability are the main problems. Allobone grafts are osteoconductive, but there are still concerns regarding the infection risks, costs, and donor availability issues. As an alternative, widely used ceramic-based synthetic bone substitutes are based alternatively on calcium (hydroxyapatite, tricalcium phosphate, calcium sulfate, calcium phosphate). Ceramic-based bone substitutes are osteoconductive, but they are weaker than cortical bone and are not osteoinductive. Bone morphogenic protein, demineralized bone matrix, and platelet-rich plasma are used to obtain an osteoinductive function. Recently, cell-based and gen-based bone substitutes were developed and studied. This paper reviews the basic information and the latest concepts on bone grafts and bone substitutes.


J Korean Fract Soc. 2020 Oct;33(4):238-244. Korean.
Published online Oct 22, 2020.
https://doi.org/10.12671/jkfs.2020.33.4.238
Copyright © 2020 The Korean Fracture Society. All rights reserved.
Review

Bone Substitutes: From Basic to Current Update

Jong Seong Han, M.D. and Hyung Keun Song, M.D.
    • Department of Orthopedic Surgery, Ajou University School of Medicine, Suwon, Korea.
  • Correspondence to: Hyung Keun Song, M.D. Department of Orthopedic Surgery, Ajou University School of Medicine, 164 WorldCup-ro, Yeongtong-gu, Suwon 16499, Korea. Tel: +82-31-219-5220, Fax: +82-31-219-5229, Email: ostrauma@ajou.ac.kr
Received October 07, 2020; Revised October 07, 2020; Accepted October 07, 2020.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bone substitutes are being used increasingly in bony surgery as more than two million bone grafts are performed worldwide per year. Autobone grafts represent the gold standard for bone grafting, but morbidity and limited availability are the main problems. Allobone grafts are osteoconductive, but there are still concerns regarding the infection risks, costs, and donor availability issues. As an alternative, widely used ceramic-based synthetic bone substitutes are based alternatively on calcium (hydroxyapatite, tricalcium phosphate, calcium sulfate, calcium phosphate). Ceramic-based bone substitutes are osteoconductive, but they are weaker than cortical bone and are not osteoinductive. Bone morphogenic protein, demineralized bone matrix, and platelet-rich plasma are used to obtain an osteoinductive function. Recently, cell-based and gen-based bone substitutes were developed and studied. This paper reviews the basic information and the latest concepts on bone grafts and bone substitutes.

Keywords
Bone graft, Bone substitute

Notes

Financial support:None.

Conflict of interests:None.

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    Bone Substitutes: From Basic to Current Update
    J Korean Fract Soc. 2020;33(4):238-244.   Published online October 31, 2020
    DOI: https://doi.org/10.12671/jkfs.2020.33.4.238
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