Journal of Musculoskeletal Trauma

Current Concepts of Vitamin D and Calcium in the Healing of Fractures: Jihyo Hwang; J Korean Fract Soc 2021;34(3):117-121. Published online July 31, 2021; DOI: https://doi.org/10.12671/jkfs.2021.34.3.117

Abstract PDF: Fragile fractures, also known as osteoporosis fractures, insufficiency fractures, and senile fractures are a significant problem encountered by orthopedic surgeons. Calcium and vitamin D are essential for maintaining bone health and deficiencies in calcium and vitamin D are major risk factors for the development of osteoporosis. Sufficient amounts of calcium are also required for fracture-callus mineralization. Hence, compromised bone repair that is frequently observed in osteoporotic patients might be attributed to calcium and vitamin D deficiencies. Consequently, calcium and vitamin D supplementation represents a potential strategy for treating compromised fracture healing in osteoporotic patients. There is some clinical evidence of the positive effect of supplementation in fracture healing and posttraumatic bone turnover, but research in this area is ongoing. Calcium and vitamin D should be the primary treatment of choice in osteopenic patients with an insufficiency of calcium and vitamin D and for the prevention of secondary osteoporotic fractures. Calcium and vitamin D can also be used as addition to other primary osteoporotic medications such as antiresorptive or bone-forming agents. The role of calcium and vitamin D in fracture healing and the therapeutic potential of calcium and vitamin D supplementation is summarized in this context.

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Tendon Healing: A Review of Basic Science and Current Progress: Young Woo Kwon, Pei Wei Wang, Jun-Ku Lee; J Korean Fract Soc 2020;33(4):227-237. Published online October 31, 2020; DOI: https://doi.org/10.12671/jkfs.2020.33.4.227

Abstract PDF: The tendon connects the muscles to the bones and transmits the loads generated by the muscles to the bones to move the joints, support the joints, and provide stability to the joints. Approximately 30% of patients complaining of musculoskeletal pain are associated with tendon disease, and approximately 50% of musculoskeletal injuries are caused by a tendon injury. Despite this frequent treatment of tendon damage, studies on the basic biology that provide scientific evidence for treatment, such as development, tendon injury, and healing, are still very limited. This review first summarizes the classification and composition of the tendon identified so far, the surrounding tissue, and the blood supply to the tendon. The limitations of the tendon recovery process after a tendon injury are also discussed. Finally, this review examines ways to improve tendon recovery and the biological approaches and tissue engineering that have been currently studied. In conclusion, innovative progress in promoting tendon healing has not been achieved despite the many advances in the basic structure of the tendon, and the cell and regulatory molecular factors involved in tendon recovery. Biological approaches and tissue engineering, which have become a recent issue, have shown many possibilities for the recovery of damaged cases, but further research will be needed until clinical application.

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Current Concepts of Bone Healing: Dong Hun Suh, Bong Mo Koo, Jong Woo Kang; J Korean Fract Soc 2020;33(3):171-177. Published online July 31, 2020; DOI: https://doi.org/10.12671/jkfs.2020.33.3.171

Abstract PDF: Bone injuries induce an inflammatory response that promotes bone healing. On the other hand, an aberrant process, where inflammation becomes chronic, can inhibit the healing of injured bone. At the first stage of the bone healing process, inflammatory cells, such as neutrophils and macrophages, are assembled and secrete various cytokines, chemokines, and growth factors. During callus formation, cells differentiated from mesenchymal stem cells, such as osteoblasts and chondrocytes, play leading roles in bone healing. Currently, various treatment modalities have been developed through the known mechanism of bone healing, and the clinical outcomes of bone defect and fracture nonunion have been good.

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Intermittent Parathyroid Hormone Treatment for Stimulation of Callus Formation in Elderly Patients: Hyung Keun Song, Sung Jun Kim, Jae Hoo Lee, Kyu Hyun Yang; J Korean Fract Soc 2012;25(4):295-299. Published online October 31, 2012; DOI: https://doi.org/10.12671/jkfs.2012.25.4.295; Correction in: J Musculoskelet Trauma 2013;26(2):170

Abstract PDF

PURPOSE
The purpose of this study was to evaluate the effect of parathyroid hormone (PTH) on fracture healing in elderly patients.
MATERIALS AND METHODS
We analyzed the radiologic results in 14 patients. Group I (n=7) was administrated intermittent PTH after surgical treatment and group II (n=7) was treated only with surgery. We checked the time of initial callus formation, bridging callus formation, and bone union through periodic follow-up radiographs by a radiologist who did not know the patient's information.
RESULTS
The mean time to initial callus formation was 6 weeks for group I, compared with 6.7 weeks for group II. The mean time to bridging callus formation was 15.9 weeks for group I, compared with 23.0 weeks for group II. The mean time to bone union was 28.7 weeks for group I, compared with 41.9 weeks for group II. The difference in the cumulative detection rate (CDR) of the initial callus formation of group I and II was not statistically significant (p=0.793). However, the CDR of the bridging callus formation and bone union for group I were higher than those of group II (p=0.008, p=0.001, respectively).
CONCLUSION
The intermittent PTH administration after surgical treatment and maximum possible preservation of the periosteum in elderly patients accelerates fracture healing.

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Effects of Extracts from Cnidium officinale and Angelica sinensis on Bone Fusion in Mice with Femoral Fracture
Sang Woo Kim, Min-Seok Oh
Journal of Korean Medicine Rehabilitation.2024; 34(2): 1. CrossRef
Timing of osteoporosis therapies following fracture: the current status
Rajan Palui, Harsh Durgia, Jayaprakash Sahoo, Dukhabandhu Naik, Sadishkumar Kamalanathan
Therapeutic Advances in Endocrinology and Metabolism.2022;[Epub] CrossRef
Effect of Postoperative Parathyroid Hormone Administration on Osteoporotic Intertrochanteric Fractures of Females
Hyun Cheol Oh, Ju Hyung Yoo, Joong Won Ha, Yung Park, Sang Hoon Park, Han Kook Yoon
Journal of the Korean Orthopaedic Association.2020; 55(3): 237. CrossRef
The role of teriparatide in tuberosity healing after reverse shoulder arthroplasty in complex proximal humeral fragility fracture
Bancha Chernchujit, Renaldi Prasetia
Journal of Orthopaedic Surgery.2018;[Epub] CrossRef
Bone Substitutes and the Advancement for Enhancing Bone Healing
Dong-Hyun Lee, Ji Wan Kim
Journal of the Korean Fracture Society.2017; 30(2): 102. CrossRef
Current Role and Application of Teriparatide in Fracture Healing of Osteoporotic Patients: A Systematic Review
Sang-Min Kim, Kyung-Chung Kang, Ji Wan Kim, Seung-Jae Lim, Myung Hoon Hahn
Journal of Bone Metabolism.2017; 24(1): 65. CrossRef
The Effect of Teriparatide on Fracture Healing of Osteoporotic Patients: A Meta-Analysis of Randomized Controlled Trials
Shenghan Lou, Houchen Lv, Guoqi Wang, Licheng Zhang, Ming Li, Zhirui Li, Lihai Zhang, Peifu Tang
BioMed Research International.2016; 2016: 1. CrossRef
A systematic review on the use of daily subcutaneous administration of teriparatide for treatment of patients with osteoporosis at high risk for fracture in Asia
J.F. Chen, K. H. Yang, Z.L. Zhang, H.C. Chang, Y. Chen, H. Sowa, S. Gürbüz
Osteoporosis International.2015; 26(1): 11. CrossRef

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The Effect of COX-2 Inhibitor on the Expression of MMP-13 during Early Fracture Healing Phase in Rats: Ki Ser Kang, Han Jun Lee, Jae Sung Lee, Ho Sung Ryu; J Korean Fract Soc 2009;22(1):45-50. Published online January 31, 2009; DOI: https://doi.org/10.12671/jkfs.2009.22.1.45

Abstract PDF: PURPOSE
This study investigated the effect of COX-2 inhibitor on the expression of MMP-13 in the healing process of fracture. MATERIAL AND METHODS: Adult Sprague-Dawley rats were divided into two groups of twenty five rats each. Unilateral femoral shaft fractures were created artificially under displacement in all two groups. COX-2 inhibitor was only given to the experimental group from the postoperative day 1. At 2 weeks after fracture the rats were sacrificed and the callus from each group was used for histologic examination and real time RT-PCR for MMP-13 expression.
RESULTS
Histologically, proliferation of osteoblasts and formation of osteoid was less abundant in the experimental group. In real time RT-PCR, the mean expression of MMP-13 is 2.84+/-2.50 in the control group compared with 1.16+/-1.05 in the experimental group.
CONCLUSION
In the early stage of fracture healing, COX-2 inhibitor suppress the expression of MMP-13.

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Treatment of Open Tibial Shaft Fractures using Unreamed Nailing: Jong Keon Oh, Chang Wug Oh, Kwon Jae Roh, Duk Moon Chung; J Korean Fract Soc 2005;18(1):22-28. Published online January 31, 2005; DOI: https://doi.org/10.12671/jkfs.2005.18.1.22

Abstract PDF

PURPOSE
To report the results of unreamed nailing using a nail with the largest possible diameter for the management of the open tibial shaft fractures.
MATERIALS AND METHODS
Nineteen patients with open tibial shaft fractures underwent unreamed nailing with the largest possible diameter according to the isthmic diameter measured on preoperative radiography. There were 1 Grade I, 6 Grade II, 9 Grade IIIa, 3 Grade IIIb open fractures. There were 4 type A, 12 type B, 3 type C fractures according to the OTA classification. Fractures were classified as The nail was introduced after gentle passage of a 7 to 8 millimeter-hand reamer.
RESULTS
Union was obtained in all cases. However 9 (47%) fractures required an additional procedures before union. In 6 cases, dynamization was done. Two of them were required exchange nailing for nonunion, 1 of two gained bony union through additional bone graft. Three of the others had gained union through exchange nailing, bone graft, bone transport respectively. There were one rotational malunion, one superfical and one deep infection. Interlocking screw breakage developed only in one patient.
CONCLUSION
Our data indicate that unreamed nailing in the management of open tibial fractures is safe and reliable method. Using a tight fitting nail with the largest possible diameter is a safe and effective way to avoid the problems of screw breakage.

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Treatment of Type IIIb Open Tibial Fractures
Seong Yeon Lim, Il Jae Lee, Jae Ho Joe, Hyung Keun Song
Journal of the Korean Fracture Society.2014; 27(4): 267. CrossRef
Management of Open Tibial Fractures: Role of Internal Fixation
Yerl-Bo Sung
Journal of the Korean Fracture Society.2007; 20(4): 349. CrossRef

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The Effect of Bone Connecting Powder on Stimulation of Bone Healing (Biomechenical study using double-blind method): Kyu Hyun Yang, Sung Hoon Jung; J Korean Soc Fract 2002;15(2):264-270. Published online April 30, 2002; DOI: https://doi.org/10.12671/jksf.2002.15.2.264

Abstract PDF: PURPOSE
To investigate the effect of bone connecting powder on stimulation of bone healing, we performed a biomechenical study using the rats in double blinded method.
MATERIALS AND METHODS
One hundred ten-week-old korean rats were used. We performed closed intramedullary nailing with #2 Kirschner wire on the right femur and then transverse fracture was created on the right femoral shaft. The rats were divided into two groups in double blind method, one group was bone connecting powder feeding group and the other was placebo group. The rats were euthenized four weeks after fracture. We measured the ultimate load, stiffness, ultimate stress by 3-point bending test using electromechanical testing machine. The code used for double blinded method was disclosed after biomechanical test.
RESULT
Biomechenical test was performed at four weeks after fracture, in which there were 38 rats alive in the study group and 36 rats alive in the placebo group. There were 5 nonunion in study group, 7 in placebo group. The ultimate load was 40.77 +/- 28.09N for study group, 32.39 +/-25.10N for placebo group and stiffness was 49.98 +/- 45.32N/mm, 40.52 +/-36.61N/mm respectively. We calculated the ultimate stress to correct the difference from each bone's shape and thickness and it was 11.017 +/- 10.170N/mm 2 , 6.659 +/-6.670N/mm 2 for each other(p=0.041).
CONCLUSION
On the basis of this biomechenical study, it may be concluded that fracture healing is stimulated by bone connecting powder.

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The Effects of aging process on fracture healing in rat callus: Sang Ho Song, Young Hee Choi, Shim Chang Gu, Sang Ho Yoo, Young Euy Park; J Korean Soc Fract 2001;14(2):135-144. Published online April 30, 2001; DOI: https://doi.org/10.12671/jksf.2001.14.2.135

Abstract PDF: PURPOSE
Patient age significantly influences the rate of fracture healing. The rate of healing declines with increasing age. The authors compared the aging effect on fracture healing in the callus of rat femur by the light microscopy.
MATERIALS AND METHODS
In this study the unilateral, closed fractures were created in the femur of 18 Sprague-Dawley rats. The rats were killed in three age group(8 weeks:7, 32weeks:6, 70weeks:5) at 2 weeks after fracture. The composition of fracture callus(new bone, cartilage, mesenchymal layer) was measured by image analyzer with H-E stain. Immunohistochemical stain (PCNA, TUNEL, TRAP) positive cells were counted for the comparing of cellular activity according to the aging.
RESULTS
The percent of intramembranous new bone in the younger rat(8 week:22.32%) was higher than the older ones(30 week:7.09%, 70 week:5.37%). The percent of PCNA positive osteoblast in the newbone decreased according to the aging(8 week:64.25%, 30 week:57.40%, 70 week:29.54%). The number of osteoclast in the osteochondral junction at the 8 week(43) was more than that of 30 week(25.57) and 72 week(29.87). The number of TRAP positive osteoclast was not different as aging, but the number of osteoclast in the osteochondral junction(5.89) was more than that in the metapyseal area(2.08).
CONCLUSIONS
More new bone was found in younger rat. There was a strong correlation (p<0.05) between age and PCNA activity. More number of active osteoblast and osteoclast was found in younger rat femoral fracture callus, which indicated rapid fracture healing in younger age.

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Stimulation of fracture Healing by Low-Intensity Pulsing Ultrasound: Kyu Hyun Yang, Chong Hyuk Choi, Jae Ho Cho; J Korean Soc Fract 1998;11(2):247-253. Published online April 30, 1998; DOI: https://doi.org/10.12671/jksf.1998.11.2.247

Abstract PDF

We performed a preliminary study to evaluate the effect of ultrasound in canine osteotomy model. Both ulna shafts were osteotomized and one side was irradiated with low-energy pulsing ultrasound, 50mW/cm2, 1 MHz, 200 microsecond bursting sine wave for 15 minutes, 6 days a week. Effect on the fracture healing was evaluated by radiologic scoring system, amount of uptake of radioactive isotope, and time to union. Results were as follows : At postoperative 2 months, means of the radiologic healing score were 4.5 in the irradiated side and 2.5 on the control side (p=0.019). Mean isotope uptake in the irradiated side was 44.4 count and 33.8 count in the control side (p=0.028). Two nonunion developed on the control side. Mean time to union of eight dogs was 2.6 months in the irradiated side and 3.1 months on the control side. Based on the cumulative union rate curve, fracture healing was stimulated and union was obtained one month faster in the irradiated side than the control side.

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Alterations in Serum Levels of Receptor Activator of Nuclear Factor-κB Ligand and Osteoprotegerin in Patients with Head Injury and Fracture
Shin Young Park, Kuen Tak Suh, Chang Hoon Ryu, Seung Hun Woo, Jung Sub Lee, Seong-Gang Kim
Journal of the Korean Fracture Society.2008; 21(2): 145. CrossRef

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Thirty-five Degree Internal Oblique Radiographs in Assessment of Tibial Fracture Healing: Eun Woo Lee, Ki Ser Kang, Soo Yong Kang, Jin Woo Lee; J Korean Soc Fract 1996;9(2):475-479. Published online April 30, 1996; DOI: https://doi.org/10.12671/jksf.1996.9.2.475

Abstract PDF: For the assessment of fracture healing, tomogram, computerized sonometry, resonant frequency analysis etc. were introduced recently, but most of orthopedic surgeons depend on plain X-ray and clinical experience. The progress of tibial fracture healing may be difficult to assess through routine radiological examination(AP and lateral). So, we intended to assess the healing of tibial fracture with 35Â° internal oblique view as well as AP and lateral. Five orthopedic surgeons assested the tibial fracture heating with only AP and lateral (group 1), and AP. lateral and 35Â° internal oblique view(group 2) in 45 tibial fractures. In the percent agreement of their assessment, Group 1 was 60% and group 2 was 76%. Group 2 was higher than group 1, especially in IM nailing and bone graft groups.The change of judgement between the two group was 18.7%, and it was higher in the distal tibial fracture, posterolateral bone graft and external device groups. In 11 Cases, the fibular fractures were overlapped with tibiai fracture in laterai view, in which cases 35Â° intelnal oblique view was useful for assessing the tibial fracture healing. We recommand 35Â° internal oblique view for assessment of tibial fracture healing before using more tophisticated and expensive procedure, especialiy in patients with posterolateral bone graft, distal libial fracture and combined fibular fracture, and probably in IM nailing and external device.

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