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Original Article
- Intermittent Parathyroid Hormone Treatment for Stimulation of Callus Formation in Elderly Patients
- Hyung Keun Song, M.D., Sung Jun Kim, M.D., Jae Hoo Lee, M.D., Kyu Hyun Yang, M.D., Ph.D.
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Journal of the Korean Fracture Society 2012;25(4):295-299.
DOI: https://doi.org/10.12671/jkfs.2012.25.4.295
Published online: October 19, 2012
Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.
†Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.
*Department of Orthopedic Surgery, Ajou University School of Medicine, Suwon, Korea.
- Address reprint requests to: Kyu Hyun Yang, M.D., Ph.D. Department of Orthopedic Surgery, Gangnam Severance Hosiptal, 211, Eonju-ro, Gangnam-gu, Seoul 135-720, Korea. Tel: 82-2-2019-3414, Fax: 82-2-573-5393, kyang@yuhs.ac
• Received: March 23, 2012 • Revised: May 3, 2012 • Accepted: June 11, 2012
Copyright © 2012 The Korean Fracture Society
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This article has been corrected. See "Erratum: Intermittent Parathyroid Hormone Treatment for Stimulation of Callus Formation in Elderly Patients" in Volume 26 on page 170.
Abstract
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Purpose
- The purpose of this study was to evaluate the effect of parathyroid hormone (PTH) on fracture healing in elderly patients.
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Materials and Methods
- We analyzed the radiologic results in 14 patients. Group I (n=7) was administrated intermittent PTH after surgical treatment and group II (n=7) was treated only with surgery. We checked the time of initial callus formation, bridging callus formation, and bone union through periodic follow-up radiographs by a radiologist who did not know the patient's information.
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Results
- The mean time to initial callus formation was 6 weeks for group I, compared with 6.7 weeks for group II. The mean time to bridging callus formation was 15.9 weeks for group I, compared with 23.0 weeks for group II. The mean time to bone union was 28.7 weeks for group I, compared with 41.9 weeks for group II. The difference in the cumulative detection rate (CDR) of the initial callus formation of group I and II was not statistically significant (p=0.793). However, the CDR of the bridging callus formation and bone union for group I were higher than those of group II (p=0.008, p=0.001, respectively).
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Conclusion
- The intermittent PTH administration after surgical treatment and maximum possible preservation of the periosteum in elderly patients accelerates fracture healing.
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REFERENCES
Fig. 1Comparison of cumulative detection rate curves on a time-dependent graph for the bridging callus formation in group I and II. Group I was statistically superior to group II (p=0.008). PTH: Parathyroid hormone.
Fig. 2Comparison of cumulative detection rate curves on a time-dependent graph for the bone union in group I and II. Group I was statistically superior to group II (p=0.001). PTH: Parathyroid hormone.
Fig. 3Comparison of cumulative detection rate (CDR) curves on a time-dependent graph for the initial callus formation in group I and II. The time represents the period beginning at the operation and is designated along the X-axis whenever positive findings were found for each curve. The difference in the CDR of group I and II was not statistically significant (p=0.793). PTH: Parathyroid hormone.
Figure & Data
REFERENCES
Citations
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Fig. 1
Comparison of cumulative detection rate curves on a time-dependent graph for the bridging callus formation in group I and II. Group I was statistically superior to group II (p=0.008). PTH: Parathyroid hormone.
Fig. 2
Comparison of cumulative detection rate curves on a time-dependent graph for the bone union in group I and II. Group I was statistically superior to group II (p=0.001). PTH: Parathyroid hormone.
Fig. 3
Comparison of cumulative detection rate (CDR) curves on a time-dependent graph for the initial callus formation in group I and II. The time represents the period beginning at the operation and is designated along the X-axis whenever positive findings were found for each curve. The difference in the CDR of group I and II was not statistically significant (p=0.793). PTH: Parathyroid hormone.
Fig. 1
Fig. 2
Fig. 3
Intermittent Parathyroid Hormone Treatment for Stimulation of Callus Formation in Elderly Patients
Details of Cases
Fx: Fracture, BMI: Body mass index, BMD: Bone mineral densitometry, PTH: Parathyroid hormone. F: Female, M: Male, HTN: Hypertension, CAOD: Coronary artery occlusive disease, DM: Diabetes mellitus.
Table 1
Details of Cases
Fx: Fracture, BMI: Body mass index, BMD: Bone mineral densitometry, PTH: Parathyroid hormone. F: Female, M: Male, HTN: Hypertension, CAOD: Coronary artery occlusive disease, DM: Diabetes mellitus.
