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Review Article from Symposium
Anti-osteoporotic Drugs and Fracture Healing Mechanism
Kyu Hyun Yang, M.D.
Journal of the Korean Fracture Society 2011;24(2):212-216.
DOI: https://doi.org/10.12671/jkfs.2011.24.2.212
Published online: April 13, 2011

Department of Orthopaedic Surgery, Gangnam Severance Hospital, Seoul, Korea.

Address reprint requests to: Kyu Hyun Yang, M.D. Department of Orthopaedic Surgery, Gangnam Severance Hospital, 146-92, Dokok-dong, Gangnam-gu, Seoul 135-720, Korea. Tel: 82-2-2019-3414, Fax: 82-2-573-5393, kyang@yuhs.ac

Copyright © 2011 The Korean Fracture Society

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  • 1. Alkhiary YM, Gerstenfeld LC, Krall E, et al. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J Bone Joint Surg Am, 2005;87:731-741.
  • 2. Aspenberg P, Genant HK, Johansson T, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res, 2010;25:404-414.
  • 3. Bobyn JD, Hacking SA, Krygier JJ, Harvey EJ, Little DG, Tanzer M. Zoledronic acid causes enhancement of bone growth into porous implants. J Bone Joint Surg Br, 2005;87:416-420.
  • 4. Cao Y, Mori S, Mashiba T, et al. Raloxifene, estrogen, and alendronate affect the processes of fracture repair differently in ovariectomized rats. J Bone Miner Res, 2002;17:2237-2246.
  • 5. Kiely P, Ward K, Bellemore C M, Briody J, Cowell CT, Little DG. Bisphosphonate rescue in distraction osteogenesis: a case series. J Pediatr Orthop, 2007;27:467-471.
  • 6. Lill CA, Hesseln J, Schlegel U, Eckhardt C, Goldhahn J, Schneider E. Biomechanical evaluation of healing in a non-critical defect in a large animal model of osteoporosis. J Orthop Res, 2003;21:836-842.
  • 7. Lindsay R, Nieves J, Formica C, et al. Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis. Lancet, 1997;350:550-555.
  • 8. Moroni A, Faldini C, Hoang-Kim A, Pegreffi F, Giannini S. Alendronate improves screw fixation in osteoporotic bone. J Bone Joint Surg Am, 2007;89:96-101.
  • 9. Odvina CV, Zerwekh JE, Rao DS, Maalouf N, Gottschalk FA, Pak CY. Severely suppressed bone turnover: a potential complication of alendronate therapy. J Clin Endocrinol Metab, 2005;90:1294-1301.
  • 10. Skripitz R, Aspenberg P. Implant fixation enhanced by intermittent treatment with parathyroid hormone. J Bone Joint Surg Br, 2001;83:437-440.
  • 11. Yang KH, Won JH, Yoon HK, Ryu JH, Choo KS, Kim JS. High concentrations of pamidronate in bone weaken the mechanical properties of intact femora in a rat model. Yonsei Med J, 2007;48:653-658.
Fig. 1
Molecular mechanism of action of bisphosphonate.
jkfs-24-212-g001.jpg
Fig. 2
Alendronate increases the callus size compared to control (OVX-ovariectomy), EE2 (estrogen) and RLX (raloxifen).
jkfs-24-212-g002.jpg
Fig. 3
Structure of multicellular remodelling units.
jkfs-24-212-g003.jpg
Fig. 4
Bisphophonate rescue regimen in case of delayed bone formation after osteotomy and distraction.
jkfs-24-212-g004.jpg
Fig. 5
Zoledronate enhances bone in-growth in porous implant.
jkfs-24-212-g005.jpg
Fig. 6
Teriparatide (1-34 PTH) injection shortened the healing time of Colles' fracture.
jkfs-24-212-g006.jpg
Fig. 7
PTH enhances bone growth around the screw and increases pull-out strength significantly compared to control.
jkfs-24-212-g007.jpg

Figure & Data

REFERENCES

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    Citations to this article as recorded by  
    • Effects of Extracts from Cnidium officinale and Angelica sinensis on Bone Fusion in Mice with Femoral Fracture
      Sang Woo Kim, Min-Seok Oh
      Journal of Korean Medicine Rehabilitation.2024; 34(2): 1.     CrossRef
    • Effect of Postoperative Parathyroid Hormone Administration on Osteoporotic Intertrochanteric Fractures of Females
      Hyun Cheol Oh, Ju Hyung Yoo, Joong Won Ha, Yung Park, Sang Hoon Park, Han Kook Yoon
      Journal of the Korean Orthopaedic Association.2020; 55(3): 237.     CrossRef
    • Medical Treatment of Osteoporosis/Prevention of Falls
      Hyoung Keun Oh
      Journal of the Korean Fracture Society.2018; 31(4): 165.     CrossRef

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      Anti-osteoporotic Drugs and Fracture Healing Mechanism
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    Anti-osteoporotic Drugs and Fracture Healing Mechanism
    Image Image Image Image Image Image Image
    Fig. 1 Molecular mechanism of action of bisphosphonate.
    Fig. 2 Alendronate increases the callus size compared to control (OVX-ovariectomy), EE2 (estrogen) and RLX (raloxifen).
    Fig. 3 Structure of multicellular remodelling units.
    Fig. 4 Bisphophonate rescue regimen in case of delayed bone formation after osteotomy and distraction.
    Fig. 5 Zoledronate enhances bone in-growth in porous implant.
    Fig. 6 Teriparatide (1-34 PTH) injection shortened the healing time of Colles' fracture.
    Fig. 7 PTH enhances bone growth around the screw and increases pull-out strength significantly compared to control.
    Anti-osteoporotic Drugs and Fracture Healing Mechanism

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