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Bone Substitutes: From Basic to Current Update
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Jong Seong Han, Hyung Keun Song
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J Korean Fract Soc 2020;33(4):238-244. Published online October 31, 2020
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DOI: https://doi.org/10.12671/jkfs.2020.33.4.238
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 Abstract
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- Bone substitutes are being used increasingly in bony surgery as more than two million bone grafts are performed worldwide per year. Autobone grafts represent the gold standard for bone grafting, but morbidity and limited availability are the main problems. Allobone grafts are osteoconductive, but there are still concerns regarding the infection risks, costs, and donor availability issues. As an alternative, widely used ceramic-based synthetic bone substitutes are based alternatively on calcium (hydroxyapatite, tricalcium phosphate, calcium sulfate, calcium phosphate). Ceramic-based bone substitutes are osteoconductive, but they are weaker than cortical bone and are not osteoinductive. Bone morphogenic protein, demineralized bone matrix, and platelet-rich plasma are used to obtain an osteoinductive function. Recently, cell-based and gen-based bone substitutes were developed and studied.
This paper reviews the basic information and the latest concepts on bone grafts and bone substitutes.
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Citations
Citations to this article as recorded by  - Tannic acid-modified magnesium oxychloride bone cement with high water resistance and osteogenic properties
Junying Chen, Yijia Guan, Yue Yang, Tingting Ma, Jinlun Feng, Wenjie Guo, Qifang Wang, Yanru Zhang, Jianguo Liao
Ceramics International.2024; 50(24): 53407. CrossRef - Surface modification of magnesium with a novel composite coating for application in bone tissue engineering
Jorgimara de O. Braga, Diogo M.M. dos Santos, Fernando Cotting, Vanessa F.C. Lins, Nádia M. Leão, Daniel C.F. Soares, Eric M. Mazzer, Manuel Houmard, Roberto B. Figueiredo, Eduardo H.M. Nunes
Surface and Coatings Technology.2022; 433: 128078. CrossRef
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