PURPOSE Receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG) have been shown to be important regulators of osteoclastogenesis during bone remodeling, and their expressions were examined during fracture healing in a mouse model of tibial fracture. However, studies linking RANKL and OPG in patients with head injury and fracture are lacking. We evaluated the changes in serum levels of RANKL and OPG in patients with head injury and fracture (head injury group) and in patients with fracture (fracture group) and compared these with levels found in healthy control subjects. MATERIALS AND METHODS 18 male patients of head injury and fracture and 20 male patients of fracture alone were enrolled. 20 healthy men were recruited to serve as controls. Within the first few hours of admission to hospital, at 4, 8 and 12 weeks after injury 20 ml of blood were obtained from 18 patients with head injury and fracture and 20 patients with fracture only. RESULTS RANKL levels were significantly lower in the head injury group than in the fracture group at 8 and 12 weeks after injury. OPG levels were significantly higher in the head injury group than in the fracture group at 4, 8 and 12 weeks after injury. RANKL/OPG ratios were significantly lower in the head injury group than in the controls immediately after and 4, 8 and 12 weeks after injury, and were significantly lower in the head injury group than in the fracture group at 8 and 12 weeks after injury. CONCLUSION We have shown changes in the profiles of RANKL, OPG and RANKL to OPG ratio. The altered RANKL, OPG and RANKL/OPG ratio in the head injury group lasted longer than in those of the fracture group.
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Affirmative Effect of Hwaweo-jeon (Huayu-jian) in Osteoblast Cells and Tibia Fracture-induced Mice Soo-Hwan Lee, Kira Parichuk, Yun-yeop Cha Journal of Korean Medicine Rehabilitation.2020; 30(1): 13. CrossRef
PURPOSE To evaluate the results of internal fixation with bifurcate angled blade plate and tension band wiring of greater tuberosity or rotator cuff for the unstable proximal humerus fracture. MATERIALS AND METHODS Nineteen cases of unstable proximal humerus fracture who were followed up for more than 1 year were treated using bifurcate angled blade plate and tension band wiring between March 2003 and March 2005. Average age of the patients was 46.5 years (range, 24 to 69), and there were 9 male and 10 female patients. The radiological results were evaluated by bony union and neck shaft angle. In addition, the clinical results were evaluated by Neer's evaluation criteria. RESULTS In 18 out of 19 cases, bony union was obtained in average 12.5 weeks after operation. The neck shaft angles of sixteen cases were between 120 and 140 degrees by Paavolainen method. According to Neer's evaluation criteria, 17 cases showed excellent or good results. CONCLUSION The patients treated using bifurcate angled blade plate and tension band wiring could exercise earlier because of good initial stability. Also, the radiological and clinical results were relatively good. The treatment of unstable proximal humerus fracture with bifurcate angled blade plate and tension band wiring was considered as a good method.
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Hemiarthoplasty with Bone Block Graft and Low Profile Prosthesis for the Comminuted Proximal Humerus Fractures Chung Hee Oh, Joo Han Oh, Sae Hoon Kim, Ki Hyun Jo, Sung Woo Bin, Hyun Sik Gong Journal of the Korean Fracture Society.2008; 21(3): 213. CrossRef
PURPOSE To evaluate the outcomes of twenty-six cases of segmental tibia fracture that were treated by closed interlocking intramedullary nailing.
MATERIAL AND METHODS: All cases were followed up for at least 1 year (average 14.3 months). Clinical results were evaluated by Klemm & Borner's scale. We analyzed the average range of the motion of the ankle and knee joint, atrophy of quadriceps muscle and angular deformity at the last follow up. We evaluated complications (new fracture of the tibia, infection, compartment syndrome, nonunion, delayed union, angular deformity and pain of ankle and knee joint). RESULTS Results were excellent in 4 cases (15.4%), good in 18 cases (69.2%), fair in 3 cases (11.5%), and poor in 1 case (3.9%). Union was obtained in 25 cases (96.1%) over an average period of 23.3 weeks. Nine cases showed intra-operative or post-operative complications: new fracture of the proximal tibia on the posteromedial side (2 cases), local infection at an entry point (2 cases), compartment syndrome (1 case), deep infection (1 case), and delayed union (3 cases). At the last follow up, angular deformity was found in 4 cases (mean of all deformities, 6 degrees): 3 cases at the proximal fracture site (2 cases of valgus deformity: 5 and 8 degrees and 1 case of varus deformity: 7 degrees) and the other case in the distal fracture site (valgus 5 degrees). Average postoperative range of motion of the knee joint was 123.7 degrees (80~135 degrees). Knee pain or limited motion occurred in 4 cases. The average range of the motion of the ankle joint was 68.1 degrees (60~70 degrees). Limited motion occurred in 4 cases (average, 10 degrees) but no case showed ankle pain. CONCLUSION Closed interlocking intramedullary nailing for segmental tibia fracture often results in complications. To minimize these complications, comprehensive evaluation of the fracture, and careful surgical treatment are required.
PURPOSE To report our experiences of treatment with reviewing literatures and articles about the fractures of plate and nonunion after open reduction and internal fixation of clavicle fracture. MATERIALS AND METHODS 9 cases among 104 cases of clavicle fractures of reoperation due to the fractures of plate or nonunion after open reduction and internal fixation were included. Treatment results were analyzed after 5 months in regard to fracture site pain, gross deformities, limitation of movement of shoulder, discomfortness of casual activity, and patients' personal satisfaction. RESULTS According to the criteria of Kang et al 9 cases were classified into excellent 2 cases, good 4 cases, fair 2 cases, poor 1 case. All cases showed bone union average 14.4(12-26) weeks after reoperation. 3 cases of complications were 3 limitation of movement of shoulder, I superficial wound infection. CONCLUSION In operative treatment of clavicle fracture more than three screws in both side of fracture line shoulder be fixated and early exercise of shoulder motion seemed to be needed. In cases of less than three screws fixated, additional external protection is thought be necessary.