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- The Effect of Safflower Seed or Matairesinol on Spontaneous Bone Formation in Surgically Induced Bone Defect in Young Rabbit
- Hae Ryong Song, Do Kyung Ra, Gon Sup Kim, Ki Churl Chang, Jae Min Hwang, Seong Chan Yeon, Hyung Bin Park, Sang Won Choi
- J Korean Soc Fract 2002;15(2):97-105. Published online April 30, 2002
- DOI: https://doi.org/10.12671/jksf.2002.15.2.97
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Abstract
PDF - PURPOSE
To investigate the effect of defatted safflower seed or matairesinol on spontaneous bone formation in surgically induced bone defects in young rabbits MATERIALS AND METHODS: Bone defects(20% of original femoral length) were created at the midshaft of the femur in 52 young rabbits and stabilized with external fixation. The periosteum was preserved. Fifty-two rabbits were divided into four groups as follows; the group I fed on safflower seed powders(30%) and normal diet(70%), the group II on matairesinol (5%) and normal diet(95%), the group III on normal diet(100%) with intravenous injection of matairesinol, the group IV on normal diet(100%). Radiographs were taken weekly to evaluate the bone regeneration and union time. Biomechanical testing on the new bone formation area was performed to measure bending stiffness. The area of new bone formation was scanned by quantitative computed tomography to measure bone mineral density(BMD).
RESULT
The mean union time(weeks) was 7.2 in the group I, 8.6 in the group II, 8.8 in the group III, and 8.5 in the group IV and was significantly different between the group I and the other groups(p<0.05). The BMD and bone strength of the callus were compared between the group I and the group IV. The mean BMD was 310.45 +/-49.58 g/mm2 in the group I and 291.16 +/-55.79 g/mm2 in the group and there was significant difference(p<0.05). The mean bending stiffness was 415.33 +/-137.18 N/mm in the group I and 358.75 +/-107.32 N/mm in the group IV and there was significant difference(p<0.05).
CONCLUSION
The diet with safflower seed powder was effective for decreasing union time and increasing bone strength of the callus formed at the bone defect whereas the diet or injection with matairesinol was not effective. More experimental studies are necessary to prove the effect of matairesinol on the callus.
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- Effect of Insertion of Bone Graft Substitutes on Consolidation of Distracted Callus: Changes of Radiography & Bone Mineral Density in the Tibia of Rabbits
- Chang Wug Oh, Poong Taek Kim, Byung Chul Park, Hae Ryong Song, Il Hyung Park, Jun Ho Baek, Hyung Jin Park
- J Korean Soc Fract 2000;13(4):687-695. Published online October 31, 2000
- DOI: https://doi.org/10.12671/jksf.2000.13.4.687
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Abstract
PDF
- PURPOSE
This study was designed to know the effect of calcium-sulfate and xenograft on the distracted callus after lengthening.
MATERIALS AND METHODS
We had operation of subperiosteal osteotomy and external fixation on the tibial diaphysis of young New Zealand White rabbits(2.0-2.5kg); after 5 days of latency period, 7 mm(1mm/day, 2 times/day) of tibial lengthening was reached in a week. At 1 week after lengthening, the 1st experimental group of 7 rabbits received a pellet of calcium sulfate(Osteoset , Wright medical, USA) in the distraction gap, and the 2nd experimental group of 7 rabbits received 5mm2 of xenogrfat(Lubboc ) in the distraction gap. But, the control group of 7 rabbits did not receive any of above materials. We compared three groups with the changes of radiographic findings at every week and bone mineral ratio(DEXA) at every two weeks.
RESULTS
The time to complete consolidation of distraction callus of both experimental group(calcium sulfate;14 weeks, xenograft; 15.4 weeks) was shorter than that of control group(16.9 weeks) in radiographic findings. Maximum value of bone mineral ratio of distraction callus was higher and the time to reach the highest value was also shortened in the both experimental group compared to control group.
CONCLUSION
By use of bone substitutes as like calcium sulfate or xenograft in the distraction callus with external fixator, it may be possible to shorten the consolidation period and the fixator-wearing period.
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