E-submission
KOTA
Search
- Page Path
- HOME > Search
Original Articles
- The Effect of Bone Connecting Powder on Stimulation of Bone Healing (Biomechenical study using double-blind method)
- Kyu Hyun Yang, Sung Hoon Jung
- J Korean Soc Fract 2002;15(2):264-270. Published online April 30, 2002
- DOI: https://doi.org/10.12671/jksf.2002.15.2.264
-
Abstract
PDF - PURPOSE
To investigate the effect of bone connecting powder on stimulation of bone healing, we performed a biomechenical study using the rats in double blinded method.
MATERIALS AND METHODS
One hundred ten-week-old korean rats were used. We performed closed intramedullary nailing with #2 Kirschner wire on the right femur and then transverse fracture was created on the right femoral shaft. The rats were divided into two groups in double blind method, one group was bone connecting powder feeding group and the other was placebo group. The rats were euthenized four weeks after fracture. We measured the ultimate load, stiffness, ultimate stress by 3-point bending test using electromechanical testing machine. The code used for double blinded method was disclosed after biomechanical test.
RESULT
Biomechenical test was performed at four weeks after fracture, in which there were 38 rats alive in the study group and 36 rats alive in the placebo group. There were 5 nonunion in study group, 7 in placebo group. The ultimate load was 40.77 +/- 28.09N for study group, 32.39 +/-25.10N for placebo group and stiffness was 49.98 +/- 45.32N/mm, 40.52 +/-36.61N/mm respectively. We calculated the ultimate stress to correct the difference from each bone's shape and thickness and it was 11.017 +/- 10.170N/mm 2 , 6.659 +/-6.670N/mm 2 for each other(p=0.041).
CONCLUSION
On the basis of this biomechenical study, it may be concluded that fracture healing is stimulated by bone connecting powder.
- 248 View
- 0 Download
- Effects of Yuhan Bone Connecting Powder on the Repair of Fractures in Rats
- Il Yong Choi, Tai Seung Kim, Il Hoon Sung, Won Kyu Kim, Yun Young Choi, Kwan Hyoung Lee, Kyu Sung Hwang
- J Korean Soc Fract 2000;13(4):1067-1079. Published online October 31, 2000
- DOI: https://doi.org/10.12671/jksf.2000.13.4.1067
-
Abstract
PDF
- OBJECTIVES
We have studied the effects of Yuhan bone connecting powder on the healing process of the frauture at the osteotomized bones in rat, using bone densitometer, X-ray and morphological studies after administration of Yuhan bone connecting powder which has been reported in China as enhancing the processes of the fracture healing.
MATERIALS AND METHODS
90 Sprague-Dawley male rats were divided into the rib and tibia osteotomy groups. Each group was subdivided into the control, low dosage and high dosage groups. Rib and tibia were osteotomized under the general anesthesia with ketamin. From the next day after operation, Yuhan bone connecting powder diluted with distilled water was administrated to low(0.68g/kg) and high(1.36g/kg) dosage groups per se. Same amount of the distilled water was used to the control group. 1.5cm long rib including the osteotomy site and whole tibia were excised. Bone densitometer using dual energy X-ray absorptiometry, radiological and morphological studies with HE stain and alcian blue(pH 2.5)-PAS stain were performed.
RESULTS
BMD showed statistically significant difference between control group, low dose group and high dose group at 2weeks after treatment(p=0.035), but did not show such a good result at 1week(p=ns) and 4weeks(p=0.091) after treatment. Radiologically, after treatment for 2 weeks, the low and high dose groups showed more active callus formation than control group. Morphologically, dilated numerous blood vessels adjacent the bony trabeculae and well developed cartilagenous callus were observed in the experimental group at the 1st week. At the 2nd week, many newly formed bony trabeculae were formed from the cartilagenous callus, and at the 4th week relatively thick compact bone and bony trabeculae were connecting the both osteotomy ends.
CONCLUSION
BMD at the osteotomy site seemed to be increased after administration with Yuhan bone connecting powder to rats, and this finding was supported radiologically at 2weeks after treatment. Morphologically, at the early stage of the fracture healing, numerous dilated blood vessels were distributed and many bony trabeculae were formed from the cartilagenous callus. At the remodelling stage relatively thick compact bone was connecting the both ends of the osteotomy site. So it is suggested that Yuhan bone connecting powder would induce enhancing the healing process of the osteotomized bone in rat through active vascularization, mineralization of the cartilage matrix, endochondral ossification and remodelling.
- 248 View
- 0 Download
First
Prev
